WZ3146

Product Name: WZ3146
CAS No.: 1214265-56-1
Chemical Name: WZ3146
Synonyms: WZ3416;WZ3146;mz3146;CS-525;MZ-3146;WZ 3146;WZ-3146;WZ3146 USP/EP/BP;WZ3146;WZ3146; WZ 3146;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamid
CBNumber: CB82500940
Molecular Formula: C24H25ClN6O2
Formula Weight: 464.95
MOL File: 1214265-56-1.mol

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WZ3146 Property

Density: 1.318
storage temp.: Store at -20°C
solubility: ≥23.25 mg/mL in DMSO with gentle warming
form: solid
pka: 12.78±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 50mg
Price: $941
Updated: 2024/03/01

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 23440
Product name: WZ3146
Packaging: 10mg
Price: $341
Updated: 2024/03/01

AK Scientific

Product number: X7481
Product name: N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
Packaging: 10mg
Price: $478
Updated: 2021/12/16

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WZ3146 Chemical Properties,Usage,Production

Uses

WZ3146 is an irreversiblely inhibitor against EGFR T790M.

Definition

ChEBI: N-[3-[[5-chloro-2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide is a member of piperazines.

Biological Activity

wz3146 is a novel, irreversible inhibitor that specifically inhibits phosphorylation of egfr(l858r0) and egfr(e746_a750) with ic50 values of 2nm each.wz3146 has been reported to inhibit the phosphorylation of egfr in the non–small-cell lung cancer (nsclc) cell lines [1]. wz3146 shows to suppress the growth of egfr t790m containing cell lines. besides, analysis of recombinant egfr t790m kinase incubated with wz3146 by electrospray mass spectrometry revealed stoichiometric addition of one inhibitor molecule to the protein. analysis of a pepsin digest of the modified protein by tandem ms identified cys 797 as the site of modification thus verifying covalent bond formation between wz3146 and egfr [2].

target

EGFR(L858R)

References

[1] thanyanan reungwetwattana, saravut j. weroha, julian r. molina. oncogenic pathways, molecularly targeted therapies, and highlighted

WZ3146 Preparation Products And Raw materials

Raw materials

Preparation Products

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WZ3146 Suppliers

China 80 United States 14 Global 94

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

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View Lastest Price from WZ3146 manufacturers

Career Henan Chemical Co

Product: WZ3146 1214265-56-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%MIN
Supply Ability: ASK
Release date: 2019-12-25

1214265-56-1, WZ3146Related Search:

WZB117 WZ4003 N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine WZ4002 WZ4141R WZ4141 Selumetinib Tideglusib WZ8040 PD184352 (CI-1040) Carfilzomib Rapamycin

WZ3416

N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamid

WZ3146;WZ3146; WZ 3146

WZ3146

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide

mz3146

MZ-3146

CS-525

N-{3-[(5-Chloro-2-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)oxy]phenyl}acrylamide

WZ 3146;WZ-3146

2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-

WZ3146 USP/EP/BP

1214265-56-1

Inhibitors